association between peptidylarginine deiminase type 4 rs1748033 polymorphism and susceptibility to rheumatoid arthritis in zahedan, southeast iran

there are controversial reports regarding the role of peptidylarginine deiminase type 4 (padi4) gene polymorphisms and risk of rheumatoid arthritis (ra). the aim of the present study was to investigate the impact of padi4 rs1748033 polymorphism and susceptibility to ra in a sample of the iranian population.this case-control study was done on 150 patients with ra and 150 healthy subjects.padi4 rs1748033 genotyping was done using amplification refractory mutation system- polymerase chain reaction (arms-pcr) assay.the  padi4  rs1748033  variant  increased  the  risk  of  ra  in  codominant  (or=1.67,95%ci=1.03-2.71, p=0.048, ct vs cc; or=2.73, 95%ci=1.25-5.97, p=0.013, tt vs cc) and dominant (or=1.84, 95%ci=1.15-2.92, p=0.014, ct+tt vs cc) tested inheritance models. in addition, the padi4 rs1748033 t allele increased the risk of ra (or=1.63,95%ci=1.16-2.29, p=0.006) in comparison with c allele.in conclusion, our finding indicated that padi4 rs1748033 gene polymorphism increased the risk of ra in a sample of the iranian population.